Pile foundations are frequently used in the construction of bridges, offshore platforms, and offshore wind turbines, which are often subjected to complex lateral cyclic loading from wind, wave, or current. These lateral loads usually come from different directions or constantly change their direction, which is ignored by most existing calculation models. A two-dimensional p -y model is proposed in this study for the lateral response of the pile subjected to multi-directional cyclic loading in sand. Without introducing additional parameters, the p -y response in two dimensions is coupled by developing the model within the framework of the bounding surface p -y model. Combined with the collapse and recompression model, the effect of sand collapse around the pile during cyclic loading is considered to approach reality. The pile lateral displacement and soil resistance are obtained in incremental form using the finite difference method in the two-dimensional case. By comparing with the model test results, it is demonstrated that the proposed model is able to reasonably predict the lateral cyclic response of the pile as well as the effects of multi-directional cyclic loading. The distribution and variation characteristics of the soil resistance are further discussed by analyzing the results calculated by the proposed model.