Atrazine (ATR) is a widely used herbicide worldwide that can cause kidney damage in humans and animals by accumulation in water and soil. Lycopene (LYC), a carotenoid with numerous biological activities, plays an important role in kidney protection due to its potent antioxidant and anti-inflammatory effects. The current study sought to investigate the role of interactions between mtDNA and the cGAS-STING signaling pathway in LYC mitigating PANoptosis and inflammation in kidneys induced by ATR exposure. In our research, 350 mice were orally administered LYC (5 mg/kg BW/day) and ATR (50 or 200 mg/kg BW/day) for 21 days. Our results reveal that ATR exposure induces a decrease in mtDNA stability, resulting in the release of mtDNA into the cytoplasm through the mPTP pore and the BAX pore and the mobilization of the cGAS-STING pathway, thereby inducing renal PANoptosis and inflammation. LYC can inhibit the above changes caused by ATR. In conclusion, LYC inhibited ATR exposure-induced histopathological changes, renal PANoptosis, and inflammation by inhibiting the cGAS-STING pathway. Our results demonstrate the positive role of LYC in ATR-induced renal injury and provide a new therapeutic target for treating renal diseases in the clinic.

The tomato (Solanum lycopersicum L.) is a very valuable horticultural crop that is produced all over the world and has a significant economic impact in Asia. Several biotic and abiotic stresses (soil -borne and foliar diseases, insect pests, drought, salt, heat, and frost) severely damage the crop, however, pose a serious threat to its output. As a result, it's crucial to make efforts to introduce valuable resistance genes into tomato from their wild relatives. This study analyzed the growth of inter and intra- specific tomato hybrids to determine the high -quality hybrids. By crossing wild (S. pimpinellifolium PI1, PI4) and domesticated tomato (S. Lycopersicum LY13, LY4, LY26, LY9, and LY11) and S. Lycopersicum cv micro -tom LY15) species, hybrids of tomato plants produced by interspecific. For morphological characteristics, the fruit weight of tomato hybrids results intermediate among prenatal lines. Results towards number of fruits per turs also show intermediate findings but LY 13 X PI4 show lesser number of fruits per truss in hybrids on the same hand LY15 XLY4 show high yield and maximum number of fruits as compared to parents. Despite of fact that the wild parent male had a strong influence on hybrids for numerous morphological traits like fruit set per truss, fruit diameter, leaf length, and fruit yield. After crossing with wild cultivars, F1 tomato hybrids also had biochemical traits in reducing sugar, non -reducing sugar, total sugar, total soluble solids, and lycopene, which were improved in cultivated tomato. The wild type of tomato played a significant part in raising the lycopene content in hybrids. Therefore, it is considered that this research would expand the gene pool available for tomato breeding globally, enabling it to better adapt to climate change and withstand biotic and abiotic stress.