The self-weight stress in multilayered soil varies with depth, and traditional consolidation research seldom takes into account the actual distribution of self-weight stress, resulting in inaccurate calculations of soil consolidation and settlement. This paper presents a semi-analytical solution for the one-dimensional nonlinear consolidation of multilayered soil, considering self-weight, time-dependent loading, and boundary time effect. The validity of the proposed solution is confirmed through comparison with existing analytical solutions and finite difference solution. Based on the proposed semi-analytical solution, this study investigates the influence of self-weight, interface parameter, soil properties, and nonlinear parameters on the consolidation characteristics of multilayered soil. The results indicate that factoring in the true distribution of self-weight leads to a faster dissipation rate of excess pore water pressure and larger settlement and settlement rate, compared to not considering self-weight. Both boundary drainage performance and soil nonlinearity have an impact on consolidation. If the boundary drainage capacity is inadequate, the influence of soil nonlinearity on consolidation diminishes.