In this research, we look at the variation of cross anisotropy as a result of the application of vacuum-assisted consolidation in very soft clays that underlie a trial embankment that was built at a site in the former Texcoco Lake, some 11 km north-east of central Mexico City. Cross-anisotropy was evaluated by referring to the cross-anisotropy index, VSH/VSV. It was used shear waves propagated horizontally (VSH) from cross-hole tests, and shear waves transmitted vertically (VSV) from seismic dilatometer and suspension logging tests. These tests were performed two months after the vacuum pumps were shut down thus, the changes induced by the vacuum-assisted consolidation of soil properties were observed from the shear wave velocities measurement. Moreover, the VSH/VSV ratio was evaluated from resonant column tests performed on soil specimens retrieved from a site near the trial embankment. These samples were trimmed horizontally and vertically and tested in the resonant column device. Field and laboratory test results showed that cross-anisotropy of the studied soft lacustrine soils is barely affected by the stress state variation induced by vacuum-assisted consolidation or by loading direction, as observed in the resonant column tests. Laboratory tests also showed that the VSH/VSV is related to the liquidity index through an empirical equation that can be used to estimate fairly well field values of VSH/VSV.