One of the major challenges for a numerical modeler/practitioner designing a sheet-pile retaining structure shoring waterfront regions under dynamic loading is to reasonably capture its seismic response solely on appropriate soil constitutive model calibration. This is particularly important as the numerical modelers usually do not have access to the dynamic centrifuge testing or large-scale 1G experimental facilities for the purpose of full-scale FE model validation based on the in-situ conditions. This paper emphasizes the significance of the consideration of initial static shear during the model calibration phase on the blind numerical predictions involving a sheet-pile wall retaining a submerged backfill. For this purpose, a strain space multiple mechanism model was initially calibrated against cyclic direct simple shear (CDSS) tests performed on the Ottawa F-65 sand under different initial states. The strain space multiple mechanism model was able to replicate the essential features in the cyclic soil response under the presence of initial static shear such as the non-occurrence of liquefaction and mobilization of shear strain limited to the compression side. The calibrated soil constitutive model employed within the FLIP-ROSE FE program was reasonably able to blind-predict the measured response from the centrifuge experiments. In particular, the measured seismic lateral displacements experienced by the retaining wall were excellently captured. Finally, this study signifies the role of the stress reversal and non-stress reversal cyclic loading scenarios in the elemental calibration on the extent of permanent deformation experienced by a sheet-pile wall under earthquake excitations having different characteristics. Overall, it is observed that calibration of a soil constitutive model by incorporating the essential features of the stress reversal and nonstress reversal unsymmetrical cyclic loading may result in the appropriate FE predictions for the sheet-pile wall deformation mechanism when subjected to earthquake excitations with different characteristics.