Particle morphology has well-known effects on the mechanical properties of granular materials as it influences particle contact and packing density. Although thermal conduction of sands also depended on such two behaviors, the effects of particle morphology on thermal conductivity are not fully understood. Several series of laboratory experiments were conducted to determine particle roundness, sphericity, and thermal conductivity of five river sands prepared with the same gradation and mineral composition but different porosities. A new predictive model was proposed within the framework of the classical Cote and Konrad's model that could capture the experimental data well. The results showed that the statistical distributions of roundness and sphericity follow the normal distribution pattern, and the expected value can be used as an evaluating index to depict the particle morphology of sand samples. Thermal conductivity of dry natural sands decreased with increasing porosity that exhibited a linear decreasing trend in a semi-logarithmic scale. The decreasing rate was found to depend on the overall morphology factor, defined as the average expected value of particle roundness and sphericity. For a given porosity, thermal conductivity increased with increasing overall morphology factor. Interestingly, thermal conductivity was less affected by the particle morphology with increasing porosity. The new model incorporating the particle morphology and mineral composition with satisfactory accuracy was far superior to the Cote and Konrad's model. Additional research is recommended to assess the effects of threedimensional particle morphology, applied stress, and particle stiffness on thermal conduction of natural sands.