There are various compounds to increase the natural resistance of wood, but they can be harmful to humans, domestic animals and the environment. Natural products are therefore being researched to ensure the sustainability of the environment, human health and reduce the use of traditional products. The objective of this research was to evaluate the efficiency of andiroba (Carapa guianenses), copaiba (Copaifera spp.) and jatropha (Jatropha curcas) oils in the biological resistance of Pinus elliottii wood to arboreal termites (Nasutitermes corniger). The andiroba and copaiba oils came from communities in the municipality of Santar & eacute;m, Par & aacute;, and the jatropha oil from Fazenda Tamandu & aacute;, in the municipality of Santa Terezinha, Paraiba. They were used pure and enriched with sublimated iodine (1, 3, and 5% concentration). The effects of volatilization and leaching on the efficiency of the solutions against Nasutitermes corniger were evaluated. The lowest mass losses and damages were for wood impregnated with copaiba oil, both pure and enriched with iodine. The samples subjected to leaching showed the greatest damage (score = 9.33). Termite mortality was 100% at the end of the assay for all the treatments tested. Copaiba oil can be an environmentally friendly alternative to protect wood, especially wood in direct contact with humans and domestic animals and exposed to environments where Nasutitermes corniger is likely to attack, as it has the lowest mass losses (7.51-6.14%). However, it is not exposed to situations that could cause leaching.

The COVID-19 pandemic caused unprecedented damage to humanity, and while vaccines have been developed, they are not fully effective against the SARS-CoV-2 virus. Limited targeted drugs, such as Remdesivir and Paxlovid, are available against the virus. Hence, there is an urgent need to explore and develop new drugs to combat COVID-19. This study focuses on exploring microbial natural products from soil-isolated bacteria Streptomyces sp. strain 196 and RI.24 as a potential source of new targeted drugs against SARS-CoV-2. Molecular docking studies were performed on holoRdRp and nsp13, two key factors responsible for virus replication factor. Our in silico studies, K-252-C aglycone indolocarbazole alkaloid (K252C) and daunorubicin were found to have better binding affinities than the respective control drugs, with K252C exhibiting binding energy of - 9.1 kcal/mol with holoRdRp and - 9.2 kcal/mol with nsp13, and daunorubicin showing binding energy at - 8.1 kcal/mol with holoRdRp and - 9.3 kcal/mol with nsp13. ADMET analysis, MD simulation, and MM/GBSA studies indicated that K252C and daunorubicin have the potential to be developed as targeted drugs against SARS-CoV-2. The study concludes that K252C and daunorubicin are potential lead compounds that might suppress the inhibition of SARS-CoV-2 replication among the tested microbial compounds and could be developed as targeted drugs against COVID-19. In the future, further in vitro studies are required to validate these findings. [GRAPHICS]