Engineered nanomaterials (ENMs) have aroused extensive interest in agricultural, industrial, and medical applications. The integration of ENMs into the agricultural systems aligns with the principles of United Nations' sustainable development goals (SDGs), circular economy (CE) and bio-economy (BE) principles. This approach offers excellent opportunities to enhance productivity and address global climate change challenges. The revelation of the adverse effects of nanomaterials (NMs) on various organisms and ecosystems, however, has fueled the debate on 'Nano-paradox' leading to emergence of a new research domain 'Nanotoxicology'. ENMs have shown different interactions with biological and environmental systems as compared to their bulk counterparts. They bioaccumulate in organisms, soils, and other environmental matrices, move through food chains and reach higher trophic levels including humans ultimately resulting in oxidative stress and cellular damage. Understanding nano-bio interactions, the mechanism of gene- and cytotoxicity, and associated potential hazards, is therefore, essential to mitigate their toxicological outputs. This review comprehensively examines the cyto- and genotoxicity mechanisms of ENMs in biological systems, covering aspects such as their entry, uptake, cellular responses, dynamic interactions in biological environments their long-term effects and environmental risk assessment (ERA). It also discusses toxicological assessment methods, regulatory policies, strategies for toxicity management/mitigation and future research directions in nanotechnology, all within the context of SDGs, CE, promoting resource efficiency and sustainability. Navigating the nano-paradox involves balancing the benefits of nanomaterials with concerns about nanotoxicity. Prioritizing thorough research on above facets can ensure sustainability and safety, enabling responsible harnessing of nanotechnology's transformative potential in various applications including mitigating global climate change and enhancing agricultural productivity.

Considering the increase in demand for rare earth elements (REEs) and their accumulation in soil ecosystems, it is crucial to understand their toxicity. However, the impact of lanthanum, yttrium and cerium oxides (La2O3, Y2O3 and CeO2, respectively) on soil organisms remains insufficiently studied. This study aims to unravel the effects of La2O3, Y2O3 and CeO2 nanoparticles (NPs) and their corresponding bulk forms (0, 156, 313, 625, 1250 and 2500 mg/kg) on the terrestrial species Enchytraeus crypticus. The effects on survival, reproduction (21 days (d)), avoidance behavior (2 d) and DNA integrity (2 and 7 d) of E. crypticus were evaluated. No significant effects on survival were observed. For La2O3, the bulk form affected more endpoints than the NPs, inducing avoidance behavior (1250 mg/kg) and DNA damage (1250 mg/kg- 2 d; 2500 mg/kg- 7 d). The Y2O3 NPs demonstrated higher toxicity than the bulk form: decreased reproduction (>= 1250 mg/kg); induced avoidance behavior (>= 625 mg/kg) and DNA damage (>= 156 mg/kg- 2 d; 2500 mg/kg- 7 d). For CeO2, both forms exhibited similar toxicity, decreasing reproduction (625 mg/kg for bulk and 2500 mg/kg for NPs) and inducing DNA damage at all tested concentrations for both forms. REEs oxides toxicity was influenced by the REEs type and concentration, exposure time and material form, suggesting different modes of action. This study highlights the distinct responses of E. crypticus after exposure to REEs oxides and shows that REEs exposure may differently affect soil organisms, emphasizing the importance of risk assessment.

The global food demand is increasing with the world population, burdening agriculture with unprecedented challenges. Agricultural techniques that ushered in the green revolution are now unsustainable, owing to population growth and climate change. The agri-tech revolution that promises a robust, efficient, and sustainable agricultural system while enhancing food security is expected to be greatly aided by advancements in nanotechnology, which have been reviewed here. Nanofertilizers and nanoinsecticides can benefit agricultural practices economically without major environment impact. Owing to their unique size and features, nanoagrochemicals provide enhanced delivery of active ingredients and increased bioavailability, and posing lesser environment hazard. Nano-agrochemicals should be improved for increased efficiency in the future. In this context, nanocomposites have drawn considerable interest with regard to food security. Nanocomposites can overcome the drawbacks of chemical fertilizers and improve plant output and nutrient bioavailability. Similarly, metallic and polymeric nanoparticles (NPs) can potentially improve sustainable agriculture via better plant development, increased nutrient uptake, and soil healing. Hence, they can be employed as nanofertilizers, nanopesticides, and nanoherbicides. Nanotechnology is also being used to enhance crop production via genetic modification of traits for efficient use of soil nutrients and higher yields. Furthermore, NPs can help plants overcome salinity stress-induced oxidative damage. We also review the fate of NPs in the soil system, plants, animals, and humans, highlight the shortcomings of previous research, and offer suggestions for toxicity studies that would aid regulatory bodies and benefit the agrochemical sector, consequently promoting efficient and sustainable use of nano-agrochemicals.