Hazardous alkylphenol wastes (HAPW) are a class of organic semisolid waste characterized by large production, complex composition and difficulties associated with recycling. Their generation and disposal lead to significantly environmental issues, including water and soil pollution, and present a substantial industrial challenge. To address these issues, a sustainable, low-carbon strategy for the high-value utilization of HAPW has been proposed. We take HAPW as a compatibilizer in the production of epoxy asphalt for road construction materials. Experimental results show that the HAPW-based epoxy asphalt containing 19.5 wt% HAPW exhibited optimal mechanical properties (tensile strength: 4.16 MPa; elongation at break: 164.92 %), exceeding industrial standards and outperforming epoxy asphalt produced using commercial cardanol through conventional processes. With a detailed molecular dynamics simulation, it is found that the HAPW plays two key roles in enhancing the interactions between epoxy resins and asphalt: (i) HAPW generates numerous hydrogen bonds with both asphalt and epoxy resin phases, strengthening noncovalent interactions and improving interfacial miscibility between the two phases. (ii) HAPW could react with the epoxy resin through the phenolic hydroxyl group, which further improves the interactions between epoxy resin and asphalt. This approach facilitates the treatment of hazardous organic waste in an environmentally sustainable and low-carbon way, enabling the recovery and repurposing of organic waste into high-valued products. Consequently, it promotes the resource utilization of industrial wastes while simultaneously contributing to a reduction in carbon emissions.