In the transitional waters of 30 to 90 m, jacket foundation has great application potential due to its advantages of light weight, high structural stiffness and good stability. In addition to the long-term normal wind and waves, the wind turbines will suffer from typhoons and waves in extreme bad weather. Currently, research on the dynamic response of jacket supported OWTs in clay under severe typhoons is very rare. The study develops a numerical method to calculate the dynamic response and fatigue damage of jacket supported OWTs under typhoon loads by incorporating a simplified single bounding surface model of clays. Through three-dimensional numerical analysis across various scenarios, this study investigates the dynamic response characteristics of jacket supported OWTs on clay soil. It also examines the impact of wind-wave coupling effects on the fatigue damage experienced by these structures. It was found that severe typhoons can lead to notable permanent tilting of the jacket foundation, thereby failing to meet the requirements of normal serviceability limits. The most critical nodes of the OWT are situated at the mudline of the pile foundations, followed closely by the bottom of the tower structure. The most significant fatigue damage occurs for wind-wave co-directional coupling loading along the orthogonal direction of the OWT. The research outcomes provide valuable guidance for enhancing the typhoon-resistant design of jacket supported OWTs.