Earthquakes are common geological disasters, and slopes under seismic loading can trigger coseismic landslides, while also becoming unstable due to accumulated damage caused by the seismic activity. Reinforced soil slopes are widely used as seismic-resistant geotechnical systems. However, traditional geosynthetics cannot sense internal damage in reinforced soil systems, and existing in-situ distributed monitoring technologies are not suitable for seismic conditions, thus limiting accurate post-earthquake stability assessments of slopes. This study presents, for the first time, the use of a batch molding process to fabricate self-sensing piezoelectric geogrids (SPGG) for distributed monitoring of soil behavior under seismic conditions. The SPGG's reinforcement and damage sensing abilities were verified through model experiments. Results show that SPGG significantly enhances soil seismic resistance and can detect soil failure locations through voltage distortions. Additionally, the tensile deformation of the reinforcement material can be quantified with sub-centimeter precision by tracking impedance changes, enabling high-precision distributed monitoring of reinforced soil under seismic conditions. Notably, when integrated with wireless transmission technology, the SPGG-based monitoring system offers a promising solution for real-time monitoring and early warning in road infrastructure, where rapid detection and response to seismic hazards are critical for mitigating catastrophic outcomes.

Rice bakanae disease is a soil-borne disease mainly caused by Fusarium fujikuroi, which seriously damages the yield and quality of rice. Phenamacril targets Myosin-5, thereby inhibiting its ATPase activity to exert an antifungal effect, demonstrating significant bioactivity against Fusarium species. However, the resistance of Fusarium fujikuroi field populations to phenamacril in Jiangsu Province in recent years remains unclear. In this study, a total of 223 Fusarium fujikuroi isolates were collected in Jiangsu Province from 2022 to 2023, with the resistance frequency increase from 25.88 % to 49.28 %. Additionally, a novel mutation type (S420I) in FfMyosin-5 was identified and confirmed by genetic transformation. The compound fitness index (CFI) revealed that the fitness of FfMyosin5(S420I) point mutants (1 x 10(5) < CFI <= 2 x 10(5)) was significantly lower than sensitive strain (CFI = 10.26 x 10(5)) in terms of mycelial growth rate, conidia production and conidia germination. In summary, the S420I mutation in FfMyosin-5 induces resistance to phenamacril while also decreased the fitness of Fusarium fujikuroi.

Dibutyl phthalate (DBP) is one of the most widely used phthalate esters (PAEs) that raise increasing ecotoxicological concerns due to their harmful effects on living organisms and ecosystems. Recently, while PAEs pollution in the Yangtze River has attracted significant attention, little research has been conducted on the impact of PAEs stress on S. prenanti, an endemic and valuable species in the Yangtze River. In this study, one control group (C-L) and three experimental groups: T1-L (3 mu g/L), T2-L (30 mu g/L), and T3-L (300 mu g/L) were established with reference to the DBP concentration in the environment. For the first time, we investigated the effects of DBP stress on the liver of S. prenanti using histomorphological, physiological, and biochemical indexes, as well as a joint multi-omics analysis. The results revealed that compared to the C-L group, liver structural damage and stress were not significant in the environmental concentration group (T1-L) and the number of differential genes and differential metabolites were lower. However, as DBP stress concentration increased, the liver damage became severe, with significant vacuolation and hemolysis observed in the T2-L and T3-L groups. The TUNEL assay revealed a significant increase in the number of apoptotic cells along with a notable rise in differential genes and metabolites in the T2-L and T3-L groups. Oxidative stress markers (T-AOC, SOD, CAT, and GSH-PX) were also significantly higher in the T2-L and T3-L groups. RNA-Seq analysis showed that the protein processing in the endoplasmic reticulum pathway was most significantly-enriched differential gene pathway shared by both C-L vs T2-L and C-L vs T3-L, with most of the genes in this pathway showing significant up-regulation. This suggests that the protein processing in the endoplasmic reticulum pathway may play a key role in protecting the liver from injuries caused by high DBP stress. Interestingly, C XI, C XII, C XIII, C XIV and C XV in the chemical carcinogenesis-reactive oxygen species pathway were significantly down-regulated in the T2-L and T3-L groups based on combined transcriptomic and metabolomic analyses, suggesting that DBP causes liver injury by disrupting mitochondria. This comprehensive histomorphometric and multi-omics study demonstrated that the current DBP concentration in the habitat of S. prenanti in the upper reaches of the Yangtze River temporarily causes less liver damage. However, with increasing of DBP concentration, DBP could still cause serious liver damage to S. prenanti. This study provides a new mechanistic understanding of the liver response mechanism of S. prenanti under different concentrations of DBP stress and offers basic data for the ecological protection of the Yangtze River.

Geosynthetics are widely used in civil engineering reinforcements owing to their high strength, acceptable toughness, and ease of transportation. However, traditional geosynthetics do not have the capability to monitor damage inside the soil. Therefore, in this paper, a new sensor-enabled piezoelectric geobelt (SPGB) is developed to measure the deformation of reinforced-soil structures. In-soil drawing tests are conducted to investigate the sensing performance of the SPGB. Variations in the voltage and impedance signals of the SPGB with the drawing displacement under different damage conditions are investigated. The results show that with the increase of drawing displacement, SPGB undergoes tensile deformation followed by pullout damage. In tensile deformation, the signal response of SPGB is related to strain. As the strain increases, the output voltage first increases and then decreases, and the impedance gradually decreases. In the pullout damage phase, the signal response of SPGB is related to the contact area between SPGB and soil. As the drawing displacement increases, the contact area between SPGB and soil gradually decreases, the output voltage gradually decreases, and the impedance gradually increases. Therefore, the SPGB, as a sensor- enabled geosynthetic, provides a reinforcing function to the soil body and simultaneously performs in-soil catastrophe identification.

Local site conditions recognized as a determining factor in assessing the extent of seismic hazard and damage distribution during earthquakes. Present study emphasizes seismic hazard of international business corridor of Agartala town capital of Tripura, one of the northeastern state of India categorized as highest seismic zone (zone V) attributing seismic response of local subsoil deposits under site-specific scenario earthquake motions including liquefaction susceptibility prediction. One-dimensional nonlinear ground response analysis with input of geotechnical parameters was carried using DEEPSOIL (2018) program across central zone of Agartala city and liquefaction susceptibility analysis are performed based on standard penetration test (SPT) utilizing well-established empirical relationship. The novelty of results lies in use of site-specific dynamic parameters of subsoil and synthetic ground motions based on scenario earthquake. Besides, numerical model was validated with a recent past liquefaction case study in Tripura which also attributes key highlight of this study. Key seismic hazard parameters in the form of peak ground acceleration (PGA), amplification factor (Af), and predominant frequencies (fn) are presented through geographical information based spatial maps. These maps provide crucial inputs for planners and designers for future urban planning along with seismic strengthening of existing infrastructures. This comprehensive approach offers new perspectives on seismic hazard assessment and future management plan in this region.

Construction on silty sand soils on the riverbank, which are typically loose, can cause geotechnical problems. Therefore, it is essential to improve their short-term and long-term behavior. Sustainable development encourages geotechnical engineers to use eco-friendly materials in soil improvement. This study investigates the effect of Kenaf fibers (KF) and Persian gum (PG) biopolymer on stabilizing silty sand with low shear strength. Short-term behavior was assessed using standard Proctor compaction, unconfined compressive strength (UCS), and indirect tensile strength (ITS) tests, while long-term performance was evaluated through the direct shear test. The effects of initial moisture content, PG and KF percentages, curing time, and temperature on mechanical properties were analyzed. Additionally, ultrasonic pulse velocity (UPV) and scanning electron microscopy (SEM) tests examined the microstructure of the improved soil. Results showed that the optimum PG and KF contents were 2.5 % and 1 % by soil weight, respectively. The UCS of samples containing these additives increased by 75 % compared to unstabilized soil. The highest UCS was achieved at 50 degrees C, with 5.1 times increase, while at 110 degrees C, it decreased by 67 % due to thermal degradation. Direct shear tests confirmed that KF reinforcement consistently improved shear strength. The UPV showed a strong correlation with UCS, supporting its use as a non-destructive evaluation method. Also, SEM analysis showed that PG enhanced particle bonding, while KF reinforcement created a denser and more interconnected soil structure. This study highlights the effectiveness of PG and KF as sustainable alternatives for soil stabilization, showing improved soil properties and environmental issues.

Offshore wind turbines (OWTs) empoly various foundation types, among which Jacket-type offshore wind turbines (JOWTs) are often used in shallow waters with challenging soil conditions due to their lattice framework foundations and multiple anchoring points. However, prolonged exposure to harsh marine environments (e.g. storms) and age-related degradation issues like corrosion, fatigue cracking, and mechanical damage increases failure risks. To address these issues, this paper introduces a Digital Healthcare Engineering (DHE) framework, which provides a proactive strategy for enhancing the safety and sustainability of JOWTs: (1) Real-time health monitoring using IoT; (2) Data transmission via advanced communication technologies; (3) Analytics and simulations using digital twins; (4) AI-powered diagnostics and recommendations; as well as (5) Predictive analysis for maintenance planning. The paper reviews recent technological advances that support each DHE module, assesses the framework's feasibility. Additionally, a prototype DHE system is proposed to enable continuous, early fault detection, and health assessment.

The widespread use of plastic agricultural films necessitates a thorough evaluation of environmental risks posed by soil microplastics (MPs). While the intestinal tract is a critical site for MP interactions in soil organisms, current research predominantly focuses on overall physiological responses, overlooking organ-specific toxic mechanisms. To address this gap, we exposed earthworms (Eisenia fetida) to polyethylene (PE) and biodegradable polylactic acid (PLA) MPs sourced from agricultural films at an environmentally realistic concentration of 1.0 g/kg. Incorporating natural earthworm mobility, we designed two exposure scenarios: migration from clean to contaminated soil (scenario A) and vice versa (scenario B). Machine learning-driven image analysis and phenotypic profiling revealed that PE induced more severe intestinal lesions than PLA, adversely affecting intestinal immune functions. Furthermore, PE resulted in greater oxidative damage and significantly activated immune proteins such as melanin and antimicrobial peptides through reprograming immune-related gene and protein pathways. Conversely, PLA predominantly disrupted intestinal digestive and absorptive functions, though the gut microbial community partially mitigated damage through structural and compositional adaptation. Compared with scenario A, earthworms in scenario B exhibited reduced tissue damage, enhanced digestive enzyme activity, and upregulated energy-related metabolites and cell proliferation genes, indicating partial recovery from MP-induced intestinal dysfunction. These findings elucidate the distinct toxicity mechanisms of conventional and biodegradable agricultural MPs on soil organisms, while the scenario-based approach advances risk assessment by aligning experimental design with real-world ecological behaviors.

Reconstructing fluvial dynamics is a fundamental requirement for understating the interaction between past environmental changes and human adaptation. This study focuses on the central part of the floodplain of the Nan River in northern Thailand that likely played a role in the catastrophic flood of 1818 CE, which damaged the ancient of Nan city and forced its relocation. We investigated nine sediment cores from the floodplain and from the eastern tributaries of the Nan River, to identify the potential source of floods in the past. By combining the analyses of sedimentary characteristics and provenance, the study reveals that the eastern tributaries were the dominant sediment source for most areas, with the Nan River only influencing areas close to its channel. According to optically stimulated luminescence dating, the highest sediment accumulation occurred during the eleventh to thirteenth centuries CE, coinciding with agricultural expansion and deforestation, suggesting increased erosion in the catchment of the tributaries. These findings challenge the assumption that the main Nan River has been the primary contributor to flooding catastrophes in the region and highlights the potential crucial role of smaller tributaries in similar settings in other parts of the globe.

Jadomycin B, produced by the soil bacterium Streptomyces venezuelae ISP5230, induces cytotoxicity in human breast cancer cells in vitro and has antitumoral effects in animal models. In models of multidrugresistant, triple-negative breast cancer, jadomycin B has shown promise as it is not a substrate of ABCB1 and ABCG2 drug efflux transporters. The generation of reactive oxygen species and inhibition of topoisomerases are potential mechanisms of jadomycin B-mediated DNA damage and apoptosis. However, the mechanisms of jadomycin B's anticancer activity have not been fully elucidated. By gradually exposing MDA-MB-231 triple-negative human breast cancer cells to jadomycin B, we hypothesized that resistance could be selected to further understand jadomycin B's pharmacological mechanisms. A 3-fold increase in the jadomycin B IC50 was observed in MDA-MB-231 cells exposed to increasing jadomycin B concentrations (0-3 mu M) over 7 months, herein 231-JB cells. The 231-JB cells were cross-resistant to jadomycin F and S but not to the comparator drugs mitoxantrone, doxorubicin, and SN-38. The 231-JB cells did not have increased mRNA expression of topoisomerase-2 nor ABCB1 and ABCG2. Cyclooxygenase-2 (COX-2) increased by 25-fold, but expression of prostaglandin E2 receptor 4 did not significantly change. Cotreatment with celecoxib (15-45 mu M), a COX-2 inhibitor, resensitized the 231-JB cells to jadomycin B (IC50 1/4 1.41 +/- 0.24 to 0.75 +/- 0.31 mu M vs 2.28 +/- 0.54 with 0 mu M celecoxib). To our knowledge, this work represents the first report of the involvement of COX-2 in jadomycin B activity in vitro, proving to be an exciting new target for the exploration of jadomycin B anticancer activity. Significance Statement: Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin production, is associated with procancer signaling. COX-2, ABCB1, and ABCG2 overexpression are typically correlated in cancer, contributing to chemotherapy resistance. We observed increased COX-2, but not ABCG2 or