Earthquake is one of the most critical hazard that damage buildings all over the world. Earthquake can result in ground shaking, soil liquefaction, damages, or even leads to complete collapse of buildings. So, buildings must be built to withstand the effect of earthquake so as to secure living conditions. Isolation method emerged as one of the efficient techniques for reducing the severe effects of earthquake. This project proposes a promising seismic isolation method by analysing different isolation method. A variety of isolation materials are available in order to reduce the seismic impact on buildings. This study investigated the efficiency of isolation materials such as polyurethane (PU) foam, coir fibre polyester composite, and geomembrane on seismic effect. In order to study the effectiveness of different isolation materials, seismic responses such as maximum roof acceleration, storey displacement, drift, and base shear of G+4 building was analysed using linear analysis by ANSYS software. Thus, this work aimed to propose the best suitable position of the most effective isolation material that reduces the seismic energy transferred. On other hand the use of this isolation method can provide an economic way to reduce the seismic energy transferred.