Natural cementation of rock debris is a spontaneous geochemical process that plays an important role in geotechnical stabilization. The focus of this study is to analyze the natural cementation phenomenon in mudslide-prone areas using mineralogical and biological methods. We analyzed the formation of the natural cementation phenomenon by studying its mineral composition, elemental endowment distribution, mechanical properties, and community structure. Similarly, simulated cementation experiments of rock debris by carbonate mineralizing bacteria were carried out in the laboratory to assess the feasibility of biomineralization in the stabilization of rock and soil. The results show that the natural cementation of rock debris in mudslide-prone areas is caused by the formation of calcite under chemical action, and microorganisms also contribute to it; this cementation has multiple environmental protection significance, including improving the compressive properties of rock debris (up to 2.58 Mpa), slowing down or preventing the occurrence of geologic hazards such as slumps, landslides, etc., and significantly decreasing the migratory properties of heavy metal ions and its ecological risks. Laboratory simulation conditions showed that carbonate mineralizing bacteria were enabled to utilize the Ca2+ provided by weathering to achieve rapid cementation of the rock debris, which played an important role in the increase of their compressive strength and the improvement of their pore parameters. This study provides a theoretical basis for future engineering applications of biomineralization technology.