The soil surrounding bucket foundations that are subjected to vertical cyclic loading would become softened but not consolidated. This would reduce the uplift resistance and even cause foundation failure. The paper firstly investigates the development, especially the dissipation of excess pore pressure and base suction (the suction between the bucket lid and soil) under vertical cyclic loading through 1 g model tests. The test results demonstrate that although base suction can bear 54 % of the uplift resistance of the bucket foundation at the beginning, the upward movement of foundation causes cracks at the soil surface, which accelerates excess pore pressure dissipation and leads to faster foundation failure. Therefore, the base suction should not be considered in the foundation design under long-term cyclic uplift loading. Then, an amended kinematic hardening model that can consider the strain softening effect of soil is employed to obtain the uplift resistance under vertical monotonic and cyclic loadings for various soil softening parameters and cyclic load level (the ratio of cyclic mean load to the monotonic ultimate uplift resistance). Through extensive fatigue analyzes with tens of thousands or even hundreds of thousands of cyclic loadings in each analysis, it is concluded that the fatigue cyclic number increases as the cyclic load level decreases or softening parameters (xi 95 and delta rem) increase. A prediction formula of fatigue curve of bucket foundation is proposed and verified to predict the fatigue cyclic number. The prediction error is within 10 %, and the formula can provide a convenient reference for the design of bucket foundation.